Take the form where numerous consonants can be interchanged into one or two open slots. With these words you see people get 4 green by guess #2 and fail. Nothing one can do, particularly if playing hard mode where you can't go fishing to rule out letters.

was one where it was SHA_E after two guesses. R and D were already out, guessed SHAKE, SHAVE, SHAPE and SHALE and the correct answer was SHAME.