It's easier to study the vaccine than natural immunity, no?
by ndroman21 (2021-04-15 11:50:01)
Edited on 2021-04-15 12:14:34

In reply to: This ties into my question further down the board  posted by elcortez01


They already have tens of thousands of people enrolled in a study and all they have to do is continue to follow up and track infection rates.

It seems much more challenging to create statistically significant data from the hundreds of thousands of people who have had natural infections with a bunch of variables, though I'm sure it is being studied somehow by someone?

I plan to get my 2nd shot next week as scheduled. I'm not personally worried about the very rare complications from the vaccines and I'll deal with a day of feeling crappy to ensure that I'm as immune as I can possibly be.


Maybe
by elcortez01  (2021-04-15 12:16:55)     cannot delete  |  Edit  |  Return to Board  |  Ignore Poster   |   Highlight Poster  |   Reply to Post

But that really has nothing to do with why we would give a passport to someone with a vaccine but not natural immunity. We have what, maybe 6 months of data on the vaccines? What about these vaccines make them better than any other vaccine in that we believe they give better protection than acquired immunity?


Because we know how long immunity from the vaccine lasts.
by ndroman21  (2021-04-15 12:24:30)     cannot delete  |  Edit  |  Return to Board  |  Ignore Poster   |   Highlight Poster  |   Reply to Post

...or at least, that it lasts a minimum time that we have not yet reached.

The six months will, hopefully, get pushed to seven, then eight. If it eventually runs out, the ongoing studies will show it, and it's likely that a booster shot will be all that is needed renew it.

I don't know if we have any idea how long natural immunity lasts, or whether it is variable based on an individual infection, because I'm not sure it's been effectively studied.

If I may ask, why do you want to avoid being vaccinated?


I don't necessarily want to avoid it
by elcortez01  (2021-04-15 12:40:52)     cannot delete  |  Edit  |  Return to Board  |  Ignore Poster   |   Highlight Poster  |   Reply to Post

I just don't particularly see the need at this point.

Admittedly it does give me pause that vaccines are being pushed so hard, not in general, but over everything we supposedly knew about acquired immunity.


What are you referring to about acquired immunity?
by ndroman21  (2021-04-15 12:48:36)     cannot delete  |  Edit  |  Return to Board  |  Ignore Poster   |   Highlight Poster  |   Reply to Post

I don't recall seeing any definitely information surrounding the duration or effectiveness of natural immunity, other than the fact that re-infections, while rare, have occurred.

Are there studies out there than pinpoint this information that I'm unaware of?


Being previously infected
by elcortez01  (2021-04-15 12:53:21)     cannot delete  |  Edit  |  Return to Board  |  Ignore Poster   |   Highlight Poster  |   Reply to Post

Perhaps I'm misunderstanding, but everything I've read pre-Covid, even from the CDC, has stated that while obviously riskier, immunity is more robust from an infection than a vaccine. Why has this changed so quickly?


I'm very curious what, exactly, you've read on this.
by ndroman21  (2021-04-15 13:12:07)     cannot delete  |  Edit  |  Return to Board  |  Ignore Poster   |   Highlight Poster  |   Reply to Post

I don't know that I've ever given it much thought, but my understanding is that natural immunity is extremely variable between people, and certainly between different viruses

We've been able to essentially eliminate some diseases with childhood vaccines/booster shots. Yet we can't completely stop the flu, and we can't do anything about the common cold.

I am unaware of any consensus surrounding the general efficacy or effectiveness of vaccines vs. natural immunity taken as a whole. I'm not even sure such a conclusion is possible.

Isn't this the reason why it takes so long to develop and study vaccines?


Here's a few results from a quick internet search
by elcortez01  (2021-04-15 13:21:58)     cannot delete  |  Edit  |  Return to Board  |  Ignore Poster   |   Highlight Poster  |   Reply to Post

From Childrens' Hospital of Philly: https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-safety/immune-system-and-health

From Michigan's Department of Health with citations to CDC: https://www.michigan.gov/documents/mdch/Waiver_Ed_Natural_Immunity_479884_7.pdf

I agree that immunity is likely variable and difficult to study.


Seems like "better" is a relative term here.
by ndroman21  (2021-04-15 13:35:21)     cannot delete  |  Edit  |  Return to Board  |  Ignore Poster   |   Highlight Poster  |   Reply to Post

From the 1st article:

"However, when scientists are designing vaccines, they determine the smallest amount of virus or bacteria needed to generate a protective immunologic response. In this situation, more is not necessarily better."

A stronger immmune response to an infection doesn't necessarily imply "better" because vaccines are specifically developed to minimize the side effects (feeling sick) of the immune response while still conferring immunity.

The larger point is that, with a novel virus, no one knows, and we shouldn't be making recommendations based on assumptions that have not yet been studied.


Unless I'm completely misunderstanding your last sentence
by elcortez01  (2021-04-15 14:45:25)     cannot delete  |  Edit  |  Return to Board  |  Ignore Poster   |   Highlight Poster  |   Reply to Post

Doesn't that also make the case that we shouldn't prioritize vaccine immunity vs. acquired immunity if and when we issue passports?


Vaccine immunity isn’t based on assumptions.
by ndroman21  (2021-04-15 15:09:36)     cannot delete  |  Edit  |  Return to Board  |  Ignore Poster   |   Highlight Poster  |   Reply to Post

It’s being continuously studied in the continuing trials.

Your statement that natural immunity is usually “better” than vaccine induced immunity relies on a pretty big assumption that this is also true for COVID.

I’m not certain if natural immunity is being studied the same way as vaccine induced immunity.. I suspect it is, but it’s more challenging and, as far as I know, we don’t have any clinical results at all similar to what we have from the vaccine trial studies.

If we do, I’d love to read about them and have the guidance change.


"Better" is not only my statement
by elcortez01  (2021-04-15 15:29:35)     cannot delete  |  Edit  |  Return to Board  |  Ignore Poster   |   Highlight Poster  |   Reply to Post

but taken directly from the scientists who published those articles, based on what I assume is 100+ years of study.

I don't think relying on that is any bigger assumption regarding Covid than it is to project the current Covid trials into the future. To be clear, I'm not arguing against the vaccines. I just think it's ludicrous to potentially base passports on them but not to consider acquired immunity as well.


They're not projecting anythiing from the trials.
by ndroman21  (2021-04-15 15:42:44)     cannot delete  |  Edit  |  Return to Board  |  Ignore Poster   |   Highlight Poster  |   Reply to Post

They are updating the guidance every month based on the ongoing results. I think they first announced 3 months or 4 months of immunity, and theyve revised that guidance now up to 6 months, I believe.

At some point, a statistically significant number of people in the trial may start to contract COVID, and that will tell us that immunity wanes in that timeframe. I assume they're then test boosters.

On you statements on natural immunity, the issue isn't with who is saying it.

The issues are:

1)The word "usually."

2)Defining a stronger immune system response as "better". It does not follow that the continuing immunity is necessarily stronger, and the statement I quoted from your article in my last post speaks directly to that point.


The only reason that one would need to include natural immunity in any sort of vaccine "passport" (which I'm against anyway) is for someone who does not want to get vaccinated, isn't it? Otherwise, they simply need to go get the shot and the point is moot.