They will likely drop points with Alisson out. They almost did already. Southampton dominated much of that match.
Salah and Van Dijk have played every minute this season including the extra time of the Super Cup. These things catch up.
Even that win against an out of form Chelsea team was essentially a tie.
If it was just the epl that would be one thing. But they’ll be spread thin with Champions league, World Cup and domestic cups. I just don’t see it happening.