In reply to: Lets the RB rest between snap and taking the handoff. posted by PWK2
Can and probably should have a mix.
If you go to the gun every time you throw, and under center, every time you run, that's telegraphing 101.
A good offense can and should do both. Pass from under center, run from the gun, etc. The formations, while important, aren't as essential as the design of the runs and passes themselves.
The positioning of the QB immediately telegraphs whether it's a run play or a pass play. Unless you're going with a quick count (e.g., first sound), it's rather easy for the defense to make pre-snap adjustments.